Glass M J, Cleary J P, Billington C J, Levine A S
Department of Psychology, University of Minnesota, Minneapolis 55455, USA.
Am J Physiol. 1997 Dec;273(6):R2040-5. doi: 10.1152/ajpregu.1997.273.6.R2040.
We tested whether carbohydrate source (corn starch, sucrose, Polycose) influences the choice between a high-fat and high-carbohydrate diet in spontaneously feeding rats and in rats stimulated to eat by neuropeptide Y (NPY) administration or food deprivation. Rats were tested under three diet options: 1) a high-fat diet versus a high-corn starch diet; 2) a high-fat diet versus a high-sucrose diet, and 3) a high-fat diet versus a high-Polycose diet. During daily and stimulated feeding rats ate more of the high-carbohydrate diet than the fat diet when the source of carbohydrate was sucrose or Polycose; however, when corn starch was provided as the carbohydrate source rats ate more of the high-fat diet. Food-deprived rats increased intake of both the high-fat and the high-carbohydrate diets, with the proportion of energy ingested from each of the diets resembling that noted during 3 days of spontaneous feeding. NPY-injected rats ate more of both the high-fat and high-carbohydrate diets during diet options 1 and 3, but not during option 2 when the high-sucrose and high-fat diets were offered concurrently. In that case, rats did not significantly increase their intake of the high-fat diet. Although carbohydrate source and NPY administration each influenced diet selection, altering the source of carbohydrate had a more marked effect.
我们测试了碳水化合物来源（玉米淀粉、蔗糖、聚葡萄糖）是否会影响自由进食大鼠以及通过注射神经肽Y（NPY）或禁食刺激进食的大鼠在高脂和高碳水化合物饮食之间的选择。大鼠在三种饮食选择下接受测试：1）高脂饮食与高玉米淀粉饮食；2）高脂饮食与高蔗糖饮食；3）高脂饮食与高聚葡萄糖饮食。在每日进食和刺激进食期间，当碳水化合物来源为蔗糖或聚葡萄糖时，大鼠摄入的高碳水化合物饮食比脂肪饮食更多；然而，当提供玉米淀粉作为碳水化合物来源时，大鼠摄入的高脂饮食更多。禁食的大鼠增加了高脂和高碳水化合物饮食的摄入量，每种饮食摄入的能量比例与自由进食3天时相似。注射NPY的大鼠在饮食选择1和3期间摄入的高脂和高碳水化合物饮食都更多，但在同时提供高蔗糖和高脂饮食的饮食选择2期间没有增加。在这种情况下，大鼠没有显著增加其高脂饮食的摄入量。尽管碳水化合物来源和注射NPY都影响饮食选择，但改变碳水化合物来源的影响更为显著。
