Kubota S, Asakura T, Kitamura K
No Shinkei Geka. 1976 Feb;4(2):163-76.
The experiment was performed on 86 cases under intraperitoneal pentobarbital anesthesia. One balloon was placed in the extradural space of right frontal region, and the other balloon was placed in the left extradural space and the intracranial pressure was measured. A needle was stereotaxically inserted into the subcortical area in order to measure the cerebral blood flow. Systemic blood pressure was recorded by inserting a catheter into the femoral artery, and electrocorticogram was also recorded. An expanding intracranial lesion was made by inflating the extradural balloon with physiological saline. The animals were arbitrarily divided into two groups.: 1) light or moderate groups which intracranial pressure before the injection of drug was below 400 mmH2O. 2) severe groups above 400 mmH2O. After the maintenance of the pressure, Solcoseryl was infused intravenously. The investigation was focused to observe whether Solcoseryl reveales any potent effect on cerebral blood flow, intracranial pressure, systemic blood pressure and on electroencephalogram in acute intracranial hypertension. Results 1) Intravenous injection of Solcoseryl had the effect of lowering intracranial pressure in the light or moderate and severe groups. Particularly, dose of 80 mg/kg showed the marked effect, though with a rebound phenomenon in the light or moderate groups. Furthermore, the effect was more marked and lasting by drip infusion of Solcoseryl and also by intravenous injection of Solcoseryl after pretreatment with hydrocortisone, and at this time no rebound phenomenon was recognized. 2) Solcoseryl had the effect of increasing the cerebral blood flow accompained with the lowering of intracranial pressure. 3) Systemic blood pressure was transiently lowered by the injection of Solcoseryl 20 mg/kg or 80 mg/kg and recovered immediately. 4) Solcoseryl had no effect on electroencephalogram in the severe groups. Conclusion On the basis of these results, it is rational to conclude that Solcoseryl could be superior agent render to lower intracranial pressure and to improve cerebral blood flow in acute intracranial hypertension.
实验在86例腹腔注射戊巴比妥麻醉的病例上进行。一个球囊置于右侧额叶硬膜外间隙，另一个球囊置于左侧硬膜外间隙并测量颅内压。通过立体定向将一根针插入皮质下区域以测量脑血流量。通过将导管插入股动脉记录全身血压，同时也记录脑电图。通过向硬膜外球囊注入生理盐水制造颅内扩张性病变。动物被随机分为两组：1）轻度或中度组，注射药物前颅内压低于400 mmHg₂O。2）重度组，颅内压高于400 mmHg₂O。在维持压力后，静脉输注舒康博。研究重点观察舒康博在急性颅内高压时对脑血流量、颅内压、全身血压和脑电图是否有任何显著作用。结果：1）静脉注射舒康博在轻度或中度组和重度组均有降低颅内压的作用。特别是，80 mg/kg剂量显示出显著效果，尽管轻度或中度组有反跳现象。此外，舒康博滴注以及在氢化可的松预处理后静脉注射舒康博的效果更显著且持久，此时未观察到反跳现象。2）舒康博在降低颅内压的同时有增加脑血流量的作用。3）注射20 mg/kg或80 mg/kg舒康博后全身血压短暂降低并立即恢复。4）舒康博在重度组对脑电图无影响。结论：基于这些结果，合理的结论是舒康博可能是急性颅内高压时降低颅内压和改善脑血流量的更佳药物。
