患有VACTERL综合征的儿童的先天性角膜麻醉
Congenital corneal anesthesia in children with the VACTERL association.
作者信息
Cruysberg J R, Draaijer R W, Pinckers A, Brunner H G
机构信息
Institute of Ophthalmology, University Hospital Nijmegen, The Netherlands.
出版信息
Am J Ophthalmol. 1998 Jan;125(1):96-8. doi: 10.1016/s0002-9394(99)80241-4.
PURPOSE
To describe ocular manifestations in patients with the VACTERL (vertebral, anal, cardiovascular, tracheoesophageal, renal, and limb defects) association.
METHOD
We reviewed the medical records of patients with the VACTERL association who had undergone treatment for amblyopia at the orthoptic department.
RESULTS
A striking similarity was found in three unrelated children, who, in addition to clinical manifestations of VACTERL association, showed total corneal anesthesia of one or both eyes that had resulted in recurrent corneal erosions, keratitis, and permanent corneal opacities. Other ocular manifestations included nonparalytic strabismus, anisometropia, and amblyopia.
CONCLUSION
Congenital corneal anesthesia may be part of the VACTERL association.
目的
描述患有VACTERL（脊柱、肛门、心血管、气管食管、肾脏和肢体缺陷）综合征患者的眼部表现。
方法
我们回顾了在斜视科接受弱视治疗的VACTERL综合征患者的病历。
结果
在三名无血缘关系的儿童中发现了显著的相似之处，他们除了有VACTERL综合征的临床表现外，还出现了单眼或双眼的完全角膜麻醉，导致反复角膜糜烂、角膜炎和永久性角膜混浊。其他眼部表现包括非麻痹性斜视、屈光参差和弱视。
结论
先天性角膜麻醉可能是VACTERL综合征的一部分。
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