角膜缘鳞状上皮发育异常的干扰素治疗
Interferon treatment for corneolimbal squamous dysplasia.
作者信息
Hu F R, Wu M J, Kuo S H
机构信息
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
出版信息
Am J Ophthalmol. 1998 Jan;125(1):118-9. doi: 10.1016/s0002-9394(99)80252-9.
PURPOSE
To report a patient with corneolimbal squamous dysplasia successfully treated with interferon therapy.
METHODS
A 78-year-old man had a gelatinous and vascularized lesion involving the left cornea and adjacent limbus. Impression cytology studied with periodic acid--Schiff-hematoxylin stain disclosed severe squamous dysplasia. Topical instillation and subconjunctival injection of interferon alpha-2b was instituted.
RESULTS
The gelatinous tumor mass involving the cornea and adjacent limbus completely resolved 2 months after interferon treatment. He showed no sign of recurrence during the 10-month follow-up.
CONCLUSION
Interferon therapy may be a therapeutic alternative for treating corneolimbal squamous dysplasia.
目的
报告一例采用干扰素治疗成功的角膜缘鳞状发育异常患者。
方法
一名78岁男性，其左眼角膜及相邻角膜缘有一个胶冻状且血管化的病变。经高碘酸 - 希夫 - 苏木精染色的印片细胞学检查显示为严重的鳞状发育异常。遂采用局部滴注及结膜下注射α - 2b干扰素进行治疗。
结果
干扰素治疗2个月后，累及角膜及相邻角膜缘的胶冻状肿瘤块完全消退。在10个月的随访期间未出现复发迹象。
结论
干扰素治疗可能是治疗角膜缘鳞状发育异常的一种治疗选择。
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