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人类下丘脑 - 垂体 - 性腺轴脉冲式分泌的综合动力学模型。

A comprehensive dynamical model of pulsatile secretion of the hypothalamo-pituitary-gonadal axis in man.

作者信息

Liu B Z, Peng J H, Sun Y C, Liu Y W

机构信息

Department of Physics, Northeast Normal University, Changchun, China.

出版信息

Comput Biol Med. 1997 Nov;27(6):507-13. doi: 10.1016/s0010-4825(97)00026-7.

DOI:10.1016/s0010-4825(97)00026-7
PMID:9437552
Abstract

We proposed a comprehensive dynamical model for the hormone secretion of the hypothalamo-pituitary-gonadal axis in man. This model is comprehensive and more reasonable than any previous model. A large number of deductions of this model agree well with experimental results.

摘要

我们提出了一个针对人类下丘脑 - 垂体 - 性腺轴激素分泌的综合动力学模型。该模型较为全面，比以往任何模型都更合理。此模型的大量推导结果与实验结果吻合良好。

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A comprehensive dynamical model of pulsatile secretion of the hypothalamo-pituitary-gonadal axis in man.人类下丘脑 - 垂体 - 性腺轴脉冲式分泌的综合动力学模型。
Comput Biol Med. 1997 Nov;27(6):507-13. doi: 10.1016/s0010-4825(97)00026-7.
2
An improved mathematical model of hormone secretion in the hypothalamo-pituitary-gonadal axis in man.一种改进的人类下丘脑 - 垂体 - 性腺轴激素分泌数学模型。
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Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig cell) defects in the healthy aging male gonadotropic axis.为期两周的脉冲式促性腺激素释放激素输注揭示了健康衰老男性性腺轴中存在的双重（下丘脑和睾丸间质细胞）缺陷。
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Further studies on hypothalamic-pituitary-testicular function in old rats.老年大鼠下丘脑-垂体-睾丸功能的进一步研究
Acta Endocrinol (Copenh). 1979 Oct;92(2):358-69. doi: 10.1530/acta.0.0920358.
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["Current testosterone status" and reserve capacity of Leydig cells in disorders of the hypothalamo-hypophyseal-testicular axis].
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A model for the control of testosterone secretion.睾酮分泌调控模型。
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The gonadal axis in men with schizophrenia.
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J Steroid Biochem. 1986 Nov;25(5B):741-7. doi: 10.1016/0022-4731(86)90303-1.

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Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring hypercortisolism as an irreversible bistable switch.基因组反馈控制与非基因组反馈控制之间的差异产生了一种以高皮质醇血症作为不可逆双稳态开关为特征的下丘脑-垂体-肾上腺（HPA）轴模型。
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