Barratt L J
Pflugers Arch. 1976 Feb 24;361(3):251-4. doi: 10.1007/BF00587289.
Microelectrodes with relatively large tips (3-5 mu O.D.) were used to measure the transepithelial potential difference (PD) of the distal tubule of the rat kidney in the control state and following i.v. administration of amiloride. This drug produced an increase in the magnitude of the positive PD in early distal segments (from +8.0 to +10.5 mV) and a change in polarity of the PD in late distal segments (from -18.0 to +2.5 mV). These data suggest that the potassium-conserving properties of the drug are due to its ability to induce an unfavorable electrochemical gradient opposing passive potassium secretion along the distal tubule.
使用尖端相对较大（外径3 - 5微米）的微电极来测量大鼠肾脏远曲小管在对照状态下以及静脉注射氨氯地平后的跨上皮电位差（PD）。该药物使早期远曲段的正PD幅度增加（从+8.0毫伏增至+10.5毫伏），并使晚期远曲段的PD极性发生改变（从 - 18.0毫伏变为+2.5毫伏）。这些数据表明，该药物的保钾特性归因于其能够诱导出不利于沿远曲小管被动分泌钾的电化学梯度。
