Wiggins J R, Bloom S
J Cardiovasc Pharmacol. 1979 Jan-Feb;1(1):69-75. doi: 10.1097/00005344-197901000-00007.
The effect of quinidine on the inotropic state was examined using small fragments of hyperpermeable ventricular muscle in vitro. In concentrations of 10(-5) and 10(-4) M, quinidine had no effect on the force of spontaneously contracting fibers. At a concentration of 10(-3) M, contractile force increased by at least twofold. We conclude that the negative inotropic action of quinidine is not by a direct action on intracellular organelles of the heart.
使用体外高渗透性心室肌小片段研究了奎尼丁对心肌收缩状态的影响。在浓度为10^(-5)和10^(-4) M时，奎尼丁对自发收缩纤维的力量没有影响。在浓度为10^(-3) M时，收缩力至少增加了两倍。我们得出结论，奎尼丁的负性肌力作用不是通过直接作用于心脏的细胞内细胞器。
