Williams-Hemby L, Porrino L J
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1083, USA.
Alcohol Clin Exp Res. 1997 Dec;21(9):1573-80.
The 2-[14C] deoxyglucose (2DG) method was used to examine the effects of the acute, intragastric (IG) administration of ethanol on rates of local cerebral glucose utilization (LCGU) in male Sprague-Dawley rats. The 2DG technique was initiated 3 min after the administration of 0.25, 1.0, or 2.0 g/kg ethanol. Each dose of ethanol examined produced a discrete pattern of change in functional activity. The administration of 0.25 g/kg ethanol increased LCGU in structures of the mesocorticolimbic and nigrostriatal circuits. The administration of 1.0 and 2.0 g/kg ethanol, however, produced a more limited pattern of changes in LCGU, with increases observed primarily in the mesocorticolimbic circuit. The increases in functional activity observed after the administration of the 0.25 g/kg ethanol dose were more widespread, and generally of larger magnitude, as compared to the 1.0 and 2.0 g/kg ethanol doses. These data indicate that structures of the mesocorticolimbic system are particularly sensitive to the effects of both low and high doses of ethanol when the effects are measured on the ascending limb of the blood ethanol curve.
采用2-[¹⁴C]脱氧葡萄糖（2DG）法，研究急性胃内（IG）给予乙醇对雄性Sprague-Dawley大鼠局部脑葡萄糖利用率（LCGU）的影响。在给予0.25、1.0或2.0 g/kg乙醇后3分钟开始采用2DG技术。所检测的每剂乙醇均产生了功能活动的离散变化模式。给予0.25 g/kg乙醇增加了中脑皮质边缘和黑质纹状体回路结构中的LCGU。然而，给予1.0和2.0 g/kg乙醇后，LCGU的变化模式更为有限，主要在中脑皮质边缘回路中观察到增加。与给予1.0和2.0 g/kg乙醇剂量相比，给予0.25 g/kg乙醇剂量后观察到的功能活动增加更为广泛，且通常幅度更大。这些数据表明，当中脑皮质边缘系统的结构在血液乙醇曲线的上升支上测量效应时，其对低剂量和高剂量乙醇的影响均特别敏感。
