Troshev K, Kolev Z, Zlateva A, Shishkov S, Pashaliev N, Raycheva-Mutafova E
Clinic for Burn Trauma and Plastic Surgery, Varna, Bulgaria.
Acta Chir Plast. 1997;39(3):97-102.
This study was conducted on 200 white Wistar rats weighing about 200 g each. The animals were divided into two equal groups--an experimental one, with Mepitel (SCA Mölnlycke) dressings, and a control group with cotton gauze dressings. Microbiological and histological examinations and measurements of the wounds made on the 3rd, 7th, 14th, 21st and 28th days after the 3rd-degree heat burn was inflicted using the standard method. The observations included burns with the spontaneous elimination of necroses and healing; wounds after operative total necrectomy of the burnt skin and spontaneous healing; and burns followed by total surgical necrectomy and grafting with allotransplants. The quantitative results reveal statistically reliable bacteriostatic activity above and under the Mepitel dressing. The histological examination reveals considerable biological activity in the tissues under the Mepitel. This manifests itself as an acceleration in the healing process in the wounds caused by burns and after necrectomy of the burnt skin. Mepitel on the allotransplant on the wound, which was left following the necrectomy of the burnt skin provokes the rapid and early rejection of the allograft. Mepitel's biological activity has also been confirmed by the statistically-reliable data relating to the dynamic changes in the length and breadth of the wounds. The authors came to the conclusion that, when applied immediately to a burn or a wound left following the necrectomy of skin burns, Mepitel suppresses the development of the microbiological flora and stimulates the normal healing process. Mepitel is not suitable for dressing allotransplants because of the rapid acceleration of their rejection.
本研究以200只体重约200克的白色Wistar大鼠为对象。将动物分为两组，每组数量相等——一组为实验组，使用美皮康（施乐辉公司）敷料；另一组为对照组，使用棉纱敷料。采用标准方法对大鼠进行三度热烧伤，分别在烧伤后第3、7、14、21和28天进行微生物学和组织学检查以及伤口测量。观察内容包括坏死组织自然脱落并愈合的烧伤；烧伤皮肤手术全切除坏死组织后自然愈合的伤口；以及烧伤后进行手术全切除坏死组织并同种异体移植的情况。定量结果显示，美皮康敷料上下均具有统计学上可靠的抑菌活性。组织学检查显示美皮康下方组织具有相当的生物活性。这表现为烧伤及烧伤皮肤切除术后伤口愈合过程加速。在烧伤皮肤切除术后伤口上的同种异体移植上使用美皮康，会引发同种异体移植物快速早期排斥反应。与伤口长度和宽度动态变化相关的统计学可靠数据也证实了美皮康的生物活性。作者得出结论，美皮康在立即应用于烧伤或皮肤烧伤切除术后留下的伤口时，可抑制微生物菌群生长并刺激正常愈合过程。由于会加速同种异体移植物的排斥反应，美皮康不适用于同种异体移植敷料。
