Lu Y, Durkin J P
Cellular Neurobiology Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada.
Immunol Res. 1997;16(4):355-74. doi: 10.1007/BF02786399.
Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracellular signals coupled to the IL-2 receptor and responsible for mediating IL-2 effects in T-cells is far less developed, and the role that protein kinase C (PKC) may play in the various cellular responses to IL-2 receptor activation is unclear. In this article we will discuss IL-2, its receptors, and IL-2 signal transduction in relation to the physiological roles PKC activation may play in IL-2-mediated activation of T-cells and other hematopoietic cells.
白细胞介素-2（IL-2）主要由活化的辅助性T细胞分泌，在免疫反应的产生和调节中起关键作用。多年来，IL-2的各种生物学功能一直是深入研究的焦点，并且已经得到了充分的阐明。相比之下，对与IL-2受体偶联并负责介导T细胞中IL-2效应的细胞内信号的了解则少得多，而且蛋白激酶C（PKC）在对IL-2受体激活的各种细胞反应中可能发挥的作用尚不清楚。在本文中，我们将讨论IL-2、其受体以及IL-2信号转导，以及PKC激活在IL-2介导的T细胞和其他造血细胞激活中可能发挥的生理作用。
