Soderberg L S, Flick J T
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Int J Immunopharmacol. 1997 May;19(5):305-10. doi: 10.1016/s0192-0561(97)00034-9.
Cyclohexyl nitrite is an abused nitrite inhalant. This is the first report of toxicity of cyclohexyl nitrite. Mice were exposed to 300-900 ppm cyclohexyl nitrite in an inhalation chamber for 45 min and then bled. Such treatment resulted in a 7-10% reduction in red blood cell counts, haemoglobin and haematocrit levels. Both blood leucocyte counts and spleen cellularity were reduced by 40%. Unlike isobutyl nitrite, subchronic treatment of mice with cyclohexyl nitrite did not impair macrophage tumoricidal activity or production of reactive nitrogen intermediates, but did modulate B and T cell mitogen responses. The data suggest that cyclohexyl nitrite had cytotoxic activity, comparable to that of isobutyl nitrite, which might be related to the anaemia reported in abusers. The immunomodulatory properties of cyclohexyl nitrite differed from those of isobutyl nitrite.
亚硝酸环己酯是一种被滥用的亚硝酸盐吸入剂。这是关于亚硝酸环己酯毒性的首次报道。将小鼠置于吸入舱中，暴露于300 - 900 ppm的亚硝酸环己酯环境中45分钟，然后取血。这种处理导致红细胞计数、血红蛋白和血细胞比容水平降低7 - 10%。血液白细胞计数和脾细胞密度均降低了40%。与亚硝酸异丁酯不同，对小鼠进行亚硝酸环己酯亚慢性处理不会损害巨噬细胞的杀肿瘤活性或活性氮中间体的产生，但会调节B细胞和T细胞有丝分裂原反应。数据表明，亚硝酸环己酯具有与亚硝酸异丁酯相当的细胞毒性活性，这可能与滥用者中报告的贫血有关。亚硝酸环己酯的免疫调节特性与亚硝酸异丁酯不同。
