猫大脑半球切除术后视网膜神经节细胞的跨神经元逆行性变性

Transneuronal retrograde degeneration of retinal ganglion cells following cerebral hemispherectomy in cats.

作者信息

Théoret H, Herbin M, Boire D, Ptito M

机构信息

Groupe de Recherche en Neuropsychologie Expérimentale, Université de Montréal, Canada.

出版信息

Brain Res. 1997 Nov 14;775(1-2):203-8. doi: 10.1016/s0006-8993(97)00949-9.

DOI:10.1016/s0006-8993(97)00949-9

PMID:9439845

Abstract

We have assessed the extent of transneuronal retrograde degeneration of retinal ganglion cells (RGCs) following the removal of a whole cerebral hemisphere at postnatal age 16 and 25 days. In the P16 animal, the nasal retina contralateral to the lesion suffered a 41% cell loss, whereas cell loss in the temporal retina ipsilateral to the lesion was 33%. Cell loss was greater in nasal retina and mainly included medium sized cells (200-600 microns2). In the P25 animal overall there was no evidence for ganglion cell loss.

摘要

我们评估了在出生后第16天和25天切除整个大脑半球后视网膜神经节细胞（RGCs）跨神经元逆行变性的程度。在出生后16天的动物中，与损伤对侧的鼻侧视网膜细胞损失了41%，而与损伤同侧的颞侧视网膜细胞损失为33%。鼻侧视网膜的细胞损失更大，主要包括中等大小的细胞（200 - 600平方微米）。在出生后25天的动物中，总体上没有证据表明神经节细胞有损失。