Verma O P, Singh L P
Am J Vet Res. 1976 Feb;37(2):233-5.
Uterine motility was studied in the anestrous goats after a series of estradiol injections was given and after estradiol-plus-progesterone treatment was administered. Estradiol (0.1 mg/kg) given alone by intramuscular route every 6 hours for 4 continuous days produced only a moderate increase in the uterine contractions during treatment, but significantly higher amplitude and frequency of contractions occurred at 2 days after treatment was stopped. The same doses of estradiol administered for a 24-hour period and followed by 4 injections of progesterone (1.0 mg/kg) given intramuscularly once a day produced a moderate response during treatment, but depressed the amplitude and the frequency of contractions after the treatment was stopped. The results indicate that the tissues primed with estrogen produced a stimulatory effect after their estrogen contents diminished. Progesterone, likewise, produced inhibition after a decrease in the progesterone contents of the uterine tissue.
在一系列雌二醇注射后以及雌二醇加孕酮治疗后，对处于乏情期的山羊子宫运动进行了研究。每6小时通过肌肉注射途径单独给予雌二醇（0.1mg/kg），连续4天，在治疗期间子宫收缩仅适度增加，但在停止治疗后2天出现显著更高的收缩幅度和频率。在24小时内给予相同剂量的雌二醇，随后每天一次肌肉注射4次孕酮（1.0mg/kg），在治疗期间产生适度反应，但在停止治疗后收缩幅度和频率降低。结果表明，用雌激素预处理的组织在其雌激素含量减少后产生刺激作用。同样，孕酮在子宫组织中孕酮含量降低后产生抑制作用。
