一些2-苯并恶唑啉酮衍生物的合成及其镇痛特性。
Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties.
作者信息
Erdogan H, Eriskon S, Demirdamar R
机构信息
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
出版信息
Boll Chim Farm. 1997 Sep;136(8):545-9.
In this study, the synthesis and analgesic activities of some new 6-acyl-3-(4-substituted benzoylmethyl)-2-benzoxazolinone derivatives are reported. Their structures were confirmed by microanalysis, IR, and NMR spectral analysis. The obtained compounds were screened for their analgesic activities. Analgesic activity of these compounds was investigated by modified Koster Test. The 11 compounds synthesized showed good analgesic activities.
本研究报道了一些新型6-酰基-3-(4-取代苯甲酰甲基)-2-苯并恶唑啉酮衍生物的合成及其镇痛活性。通过微量分析、红外光谱和核磁共振光谱分析对其结构进行了确证。对所制得的化合物进行了镇痛活性筛选。采用改良的科斯特试验研究了这些化合物的镇痛活性。合成的11种化合物显示出良好的镇痛活性。
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