Yaqoob P, Knapper J A, Webb D H, Williams C M, Newsholme E A, Calder P C
Department of Biochemistry, University of Oxford, United Kingdom.
Am J Clin Nutr. 1998 Jan;67(1):129-35. doi: 10.1093/ajcn/67.1.129.
Consumption of diets rich in monounsaturated fatty acids (MUFAs) has been linked with a low prevalence of atherosclerosis and there has been great interest in the effects of MUFAs on lipoprotein metabolism. Less attention has been paid to the effects of MUFAs on the immune system, yet cells of the immune system are an inherent part of the inflammatory events involved in atherosclerosis and several animal studies showed that olive oil has some potent immunomodulatory actions. We therefore considered it important to investigate the effects of chronic consumption of MUFAs on several immune cell functions in healthy humans. Healthy middle-aged males entered a double-blind, randomized, controlled trial in which they consumed either a MUFA diet or a control diet for 2 mo. There was a significant decrease in the expression of intercellular adhesion molecule 1 by peripheral blood mononuclear cells from subjects consuming the MUFA diet. Consumption of the MUFA diet did not affect natural killer cell activity or proliferation of mitogen-stimulated leukocytes. The effects of a MUFA-rich diet on adhesion molecule expression may have implications for the influence of dietary fat on inflammatory diseases, including atherosclerosis.
食用富含单不饱和脂肪酸（MUFA）的饮食与动脉粥样硬化的低患病率有关，并且人们对MUFA对脂蛋白代谢的影响非常感兴趣。然而，MUFA对免疫系统的影响却较少受到关注，而免疫系统的细胞是动脉粥样硬化相关炎症事件的固有组成部分，多项动物研究表明橄榄油具有一些强大的免疫调节作用。因此，我们认为研究长期食用MUFA对健康人类几种免疫细胞功能的影响很重要。健康的中年男性参加了一项双盲、随机、对照试验，他们食用MUFA饮食或对照饮食2个月。食用MUFA饮食的受试者外周血单核细胞中细胞间黏附分子1的表达显著降低。食用MUFA饮食并未影响自然杀伤细胞活性或丝裂原刺激的白细胞增殖。富含MUFA的饮食对黏附分子表达的影响可能对饮食脂肪对包括动脉粥样硬化在内的炎症性疾病的影响具有重要意义。
