在猪痢疾蛇形螺旋体（B204）中鉴定出一组相关基因，预计这些基因编码紧密相关的39千道尔顿胞外蛋白。
Identification of a linked set of genes in Serpulina hyodysenteriae (B204) predicted to encode closely related 39-kilodalton extracytoplasmic proteins.
作者信息
Gabe J D, Dragon E, Chang R J, McCaman M T
机构信息
Point Biomedical, Inc., San Carlos, California 94070, USA.
出版信息
J Bacteriol. 1998 Jan;180(2):444-8. doi: 10.1128/JB.180.2.444-448.1998.
Abstract
A tandem pair of nearly identical genes from Serpulina hyodysenteriae (B204) were cloned and sequenced. The full open reading frame of one gene and the partial open reading frame of the neighboring gene appear to encode secreted proteins which are homologous to, yet distinct from, the 39-kDa extracytoplasmic protein purified from the membrane fraction of S. hyodysenteriae. We have designated these newly identified genes vspA and vspB (for variable surface protein).
摘要
克隆并测序了来自猪痢疾蛇形螺旋体（B204）的一对几乎相同的串联基因。其中一个基因的完整开放阅读框和相邻基因的部分开放阅读框似乎编码分泌蛋白，这些蛋白与从猪痢疾蛇形螺旋体膜组分中纯化的39 kDa胞外蛋白同源，但又有所不同。我们将这些新鉴定的基因命名为vspA和vspB（可变表面蛋白）。
相似文献
1
Identification of a linked set of genes in Serpulina hyodysenteriae (B204) predicted to encode closely related 39-kilodalton extracytoplasmic proteins.在猪痢疾蛇形螺旋体（B204）中鉴定出一组相关基因，预计这些基因编码紧密相关的39千道尔顿胞外蛋白。
J Bacteriol. 1998 Jan;180(2):444-8. doi: 10.1128/JB.180.2.444-448.1998.
2
Sequence characterization of two new members of a multi-gene family in Serpulina hyodysenteriae (B204) with homology to a 39 kDa surface exposed protein: vspC and D.
Vet Microbiol. 1999 Aug 31;68(3-4):273-83. doi: 10.1016/s0378-1135(99)00104-2.
3
Isolation of extracytoplasmic proteins from Serpulina hyodysenteriae B204 and molecular cloning of the flaB1 gene encoding a 38-kilodalton flagellar protein.从猪痢疾蛇形螺旋体B204中分离胞外蛋白并对编码38千道尔顿鞭毛蛋白的flaB1基因进行分子克隆。
Infect Immun. 1995 Jan;63(1):142-8. doi: 10.1128/iai.63.1.142-148.1995.
4
Characterization of three putative Serpulina hyodysenteriae hemolysins.三种假定的猪痢疾蛇形螺旋体溶血素的特性分析。
Microb Pathog. 1994 Apr;16(4):269-82. doi: 10.1006/mpat.1994.1028.
5
Brachyspira hyodysenteriae contains eight linked gene copies related to an expressed 39-kDa surface protein.猪痢疾短螺旋体含有八个与一种表达的39 kDa表面蛋白相关的连锁基因拷贝。
Microbes Infect. 2003 Jan;5(1):1-6. doi: 10.1016/s1286-4579(02)00048-5.
6
Molecular analysis of a flagellar core protein gene of Serpulina (Treponema) hyodysenteriae.猪痢疾蛇形螺旋体（密螺旋体）鞭毛核心蛋白基因的分子分析
J Gen Microbiol. 1993 Aug;139(8):1701-6. doi: 10.1099/00221287-139-8-1701.
7
Cloning of a beta-hemolysin gene of Brachyspira (Serpulina) hyodysenteriae and its expression in Escherichia coli.猪痢疾短螺旋体（蛇形螺旋体属）β-溶血素基因的克隆及其在大肠杆菌中的表达。
Infect Immun. 2001 Feb;69(2):706-11. doi: 10.1128/IAI.69.2.706-711.2001.
8
Identification of the gene encoding BmpB, a 30 kDa outer envelope lipoprotein of Brachyspira (Serpulina) hyodysenteriae, and immunogenicity of recombinant BmpB in mice and pigs.猪痢疾短螺旋体（蛇螺旋体属）30 kDa外膜脂蛋白BmpB编码基因的鉴定及其重组蛋白在小鼠和猪体内的免疫原性
Vet Microbiol. 2000 Oct 1;76(3):245-57. doi: 10.1016/s0378-1135(00)00244-3.
9
Inactivation of Serpulina hyodysenteriae flaA1 and flaB1 periplasmic flagellar genes by electroporation-mediated allelic exchange.通过电穿孔介导的等位基因交换使猪痢疾蛇形螺旋体flaA1和flaB1周质鞭毛基因失活
J Bacteriol. 1995 Oct;177(20):5959-70. doi: 10.1128/jb.177.20.5959-5970.1995.
10
Physical and genetic map of the Serpulina hyodysenteriae B78T chromosome.猪痢疾蛇形螺旋体B78T染色体的物理图谱和遗传图谱。
J Bacteriol. 1994 Feb;176(4):1087-92. doi: 10.1128/jb.176.4.1087-1092.1994.
引用本文的文献
1
and Proteins Recognized by Sera of Challenged Pigs.以及受挑战猪血清识别的蛋白质。
Front Microbiol. 2017 May 4;8:723. doi: 10.3389/fmicb.2017.00723. eCollection 2017.
2
Adherence of Brachyspira hyodysenteriae to porcine intestinal epithelial cells is inhibited by antibodies against outer membrane proteins.猪痢疾短螺旋体黏附至猪肠上皮细胞被抗其外膜蛋白抗体所抑制。
Curr Microbiol. 2013 Mar;66(3):286-92. doi: 10.1007/s00284-012-0267-4. Epub 2012 Nov 29.
3
Differential expression of the Bhmp39 major outer membrane proteins of Brachyspira hyodysenteriae.猪痢疾短螺旋体Bhmp39主要外膜蛋白的差异表达
Infect Immun. 2006 Jun;74(6):3271-6. doi: 10.1128/IAI.02000-05.
4
Outer membrane proteins of pathogenic spirochetes.致病性螺旋体的外膜蛋白
FEMS Microbiol Rev. 2004 Jun;28(3):291-318. doi: 10.1016/j.femsre.2003.10.004.
5
Characterization of a periplasmic ATP-binding cassette iron import system of Brachyspira (Serpulina) hyodysenteriae.猪痢疾短螺旋体（蛇形螺旋体）周质ATP结合盒式铁导入系统的特性分析
J Bacteriol. 1999 Nov;181(22):6948-57. doi: 10.1128/JB.181.22.6948-6957.1999.
本文引用的文献
1
Dual flaA1 flaB1 mutant of Serpulina hyodysenteriae expressing periplasmic flagella is severely attenuated in a murine model of swine dysentery.表达周质鞭毛的猪痢疾蛇形螺旋体双flaA1 flaB1突变体在猪痢疾小鼠模型中严重减毒。
Infect Immun. 1996 Oct;64(10):4154-62. doi: 10.1128/iai.64.10.4154-4162.1996.
2
DNA repeats identify novel virulence genes in Haemophilus influenzae.DNA重复序列鉴定出流感嗜血杆菌中的新型毒力基因。
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11121-5. doi: 10.1073/pnas.93.20.11121.
3
Swine dysentery: more unknown than known.猪痢疾：未知多于已知。
Vet Microbiol. 1995 Oct;46(4):347-60. doi: 10.1016/0378-1135(95)00049-g.
4
Bacterial antigenic variation, host immune response, and pathogen-host coevolution.细菌抗原变异、宿主免疫反应与病原体-宿主协同进化。
Infect Immun. 1993 Jun;61(6):2273-6. doi: 10.1128/iai.61.6.2273-2276.1993.
5
Molecular cloning, expression, and DNA sequence analysis of the gene that encodes the 16-kilodalton outer membrane lipoprotein of Serpulina hyodysenteriae.猪痢疾蛇形螺旋体16千道尔顿外膜脂蛋白编码基因的分子克隆、表达及DNA序列分析
Infect Immun. 1993 Mar;61(3):1136-40. doi: 10.1128/iai.61.3.1136-1140.1993.
6
Molecular analysis of a flagellar core protein gene of Serpulina (Treponema) hyodysenteriae.猪痢疾蛇形螺旋体（密螺旋体）鞭毛核心蛋白基因的分子分析
J Gen Microbiol. 1993 Aug;139(8):1701-6. doi: 10.1099/00221287-139-8-1701.
7
Characterization of the prtA and prtB genes of Erwinia chrysanthemi EC16.
Gene. 1993 Oct 29;133(1):115-8. doi: 10.1016/0378-1119(93)90234-t.
8
Reduced virulence of Serpulina hyodysenteriae hemolysin-negative mutants in pigs and their potential to protect pigs against challenge with a virulent strain.猪痢疾蛇形螺旋体溶血素阴性突变体在猪体内的毒力降低及其保护猪抵御强毒株攻击的潜力。
Infect Immun. 1994 Jun;62(6):2244-8. doi: 10.1128/iai.62.6.2244-2248.1994.
9
Physical and genetic map of the Serpulina hyodysenteriae B78T chromosome.猪痢疾蛇形螺旋体B78T染色体的物理图谱和遗传图谱。
J Bacteriol. 1994 Feb;176(4):1087-92. doi: 10.1128/jb.176.4.1087-1092.1994.
10
Characterization of three putative Serpulina hyodysenteriae hemolysins.三种假定的猪痢疾蛇形螺旋体溶血素的特性分析。
Microb Pathog. 1994 Apr;16(4):269-82. doi: 10.1006/mpat.1994.1028.
Zotero 插件