Kuz'mina L P
Institut meditsiny truda RAMN, Moskva.
Med Tr Prom Ekol. 1997(9):26-30.
Electrophoresis and isoelectric focusing assessed distribution of phenotypic and gene frequency for 7 highly polymorphic proteins in 163 patients having occupational chronic bronchitis, pneumoconiosis and bronchial asthma. Phenotypic frequency studies, when compared to the reference group, revealed significant differences in the following parameters: proteinase inhibitor, 3rd component of complement, transferrin, serum blood-group specific component, phosphoglucomutase of RBC. Gene frequency studies revealed the significant differences in 3rd component of complement (C3), transferrin (Tf) and phosphoglucomutase of RBC (PGM): the patients demonstrated increased amounts of C3 F, Tf C3 and PGM 2b alleles. The results could be used for individual forecasting the risk of occupational diseases and for choosing the individual prophylactics.
电泳和等电聚焦评估了163例职业性慢性支气管炎、尘肺病和支气管哮喘患者中7种高度多态性蛋白质的表型和基因频率分布。与参考组相比，表型频率研究显示以下参数存在显著差异：蛋白酶抑制剂、补体第三成分、转铁蛋白、血清血型特异性成分、红细胞磷酸葡萄糖变位酶。基因频率研究显示补体第三成分（C3）、转铁蛋白（Tf）和红细胞磷酸葡萄糖变位酶（PGM）存在显著差异：患者表现出C3 F、Tf C3和PGM 2b等位基因数量增加。这些结果可用于个体预测职业病风险和选择个体预防措施。
