Bláha V, Simek J
Klinika gerontologická a metabolická, Fakultní nemocnice, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1995;38(1):37-55.
Liver regeneration means the ability of the liver to restore the initial cellular mass after damage of various etiology. The primary mechanism of liver regeneration is not clearly defined yet. According to the recent knowledge the liver regeneration is directed by co-acting of many factors and events, among which the metabolic changes in regenerating liver tissue play important role. The aim of this study is to summarize the most important metabolic changes in the early steps of liver regeneration. The study presents the changes, which are taking place in the liver and in the other tissues and organs during liver regeneration, particularly after partial hepatectomy, but also in other types of liver damage. In the beginning the short overview of genetic changes, which enable the development of metabolic changes, is presented. After that the attention is drawn to the carbohydrate, lipid and protein metabolism. In the part, discussing the lipids, the results of experiments, in which the authors followed the influencing of liver regeneration in the rat after partial hepatectomy by means of parenteral and enteral application of various types of lipids and lipids combined with carnitine, is presented. In the next part the study discusses the metabolism of protein kinases and/or ions and trace elements. The energy metabolism as the necessary part of metabolic events is mentioned after that. In the last part the study draws attention to enzymatic retrodifferentiation in regenerating liver.
肝脏再生是指肝脏在受到各种病因损伤后恢复初始细胞量的能力。肝脏再生的主要机制尚未明确界定。根据最新研究，肝脏再生是由多种因素和事件共同作用所引导的，其中再生肝组织中的代谢变化起着重要作用。本研究的目的是总结肝脏再生早期阶段最重要的代谢变化。该研究呈现了肝脏再生过程中，特别是在部分肝切除术后，以及在其他类型肝脏损伤时，肝脏及其他组织和器官所发生的变化。首先简要概述了促成代谢变化的基因变化。之后重点讨论了碳水化合物、脂质和蛋白质代谢。在讨论脂质的部分，介绍了作者通过肠外和肠内应用各种类型的脂质以及脂质与肉碱组合，观察其对大鼠部分肝切除术后肝脏再生影响的实验结果。在下一部分，研究讨论了蛋白激酶和/或离子及微量元素的代谢。随后提到了作为代谢事件必要组成部分的能量代谢。在最后一部分，研究关注了再生肝脏中的酶促逆向分化。
