Schweppe K W
Kreiskrankenhaus Ammerland, Westerstede.
Zentralbl Gynakol. 1997;119 Suppl 2:64-9.
Endometriosis is a chronic benign proliferative disease with high risk of recurrences, despite of medical and/or surgical treatment. The variation and severity of symptoms reduce the quality of life, the ability of working and the sexual behaviour. Medical cure of symptoms is a central concept in the therapeutic strategy. Low dose progestins have shown to be effective in the clinical routine since several decades although scientific data are rare and insufficient about the mechanism of action of these substances. Subjective and biochemical side effects are important for the choice of a specific progestin. The dosage is dependent of the biological activity of the drug, especially the effect on the endometrium. On the endometriotic implants and cysts high dose therapy with progestins induces the same regressive changes as complete estrogen deprivation by reversible "medical castration".
子宫内膜异位症是一种慢性良性增殖性疾病，尽管进行了药物和/或手术治疗，但复发风险很高。症状的多样性和严重程度降低了生活质量、工作能力和性行为。症状的药物治疗是治疗策略的核心概念。几十年来，低剂量孕激素在临床实践中已显示出有效性，尽管关于这些物质作用机制的科学数据很少且不充分。主观和生化副作用对于特定孕激素的选择很重要。剂量取决于药物的生物活性，尤其是对子宫内膜的作用。在子宫内膜异位植入物和囊肿上，高剂量孕激素治疗会引起与通过可逆性“药物去势”完全剥夺雌激素相同的退行性变化。
