线粒体蛋白质编码基因中的环状密码。

A circular code in the protein coding genes of mitochondria.

作者信息

Arquès D G, Michel C J

机构信息

Equipe de Biologie Théorique, Université de Marne la Vallée, Institut Gaspard Monge, 2 rue de la Butte Verte, 93160 Noisy le Grand, France.

出版信息

J Theor Biol. 1997 Dec 7;189(3):273-90. doi: 10.1006/jtbi.1997.0513.

DOI:10.1006/jtbi.1997.0513

PMID:9441820

Abstract

A new maximal circular code X0(MIT) with two permutated maximal circular codes X1(MIT) and X2(MIT) is identified in the protein coding genes of mitochondria. The three subsets of 20 trinucleotides X0(MIT)={ACA, ACC, ATA, ATC, CTA, CTC, GAA, GAC, GAT, GCA, GCC, GCT, GGA, GGC, GGT, GTA, GTC, GTT, TTA, TTC}, X1(MIT) and X2(MIT) are in frame 0 (reading frame), 1 and 2 respectively. X1(MIT) and X2(MIT) are deduced by one and two circular permutations of X0(MIT) respectively. The code X0(MIT) has four important properties: a length of the minimal window to automatically retrieve frame 0 which is equal to five nucleotides; an occurrence probability equal to 6.3 x 10(-5); a low frequency (12% in average) of misplaced trinucleotides in the shifted frames; and an occurrence of four types of nucleotides in the first and second trinucleotide sites but no nucleotide G in the third trinucleotide site. Several biological consequences are presented in the Discussion.

摘要

在线粒体的蛋白质编码基因中，发现了一种新的最大循环码X0（MIT），它带有两个经过排列的最大循环码X1（MIT）和X2（MIT）。20个三核苷酸的三个子集X0（MIT）={ACA, ACC, ATA, ATC, CTA, CTC, GAA, GAC, GAT, GCA, GCC, GCT, GGA, GGC, GGT, GTA, GTC, GTT, TTA, TTC}、X1（MIT）和X2（MIT）分别处于第0（读码框）、1和2读码框中。X1（MIT）和X2（MIT）分别是通过对X0（MIT）进行一次和两次循环排列推导出来的。码X0（MIT）具有四个重要特性：自动检索第0读码框的最小窗口长度等于五个核苷酸；出现概率等于6.3×10⁻⁵；在移码中三核苷酸错配的频率较低（平均为12%）；以及在第一个和第二个三核苷酸位点出现四种类型的核苷酸，但在第三个三核苷酸位点没有核苷酸G。讨论部分阐述了几个生物学后果。