Gomez del Arco P, Martínez-Martínez S, Calvo V, Armesilla A L, Redondo J M
Servicio de Inmunología, Hospital de la Princesa, Madrid, Spain.
Immunobiology. 1997 Dec;198(1-3):273-8. doi: 10.1016/S0171-2985(97)80047-2.
Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.
转录因子AP-1的活性受不同的丝裂原活化蛋白激酶（MAPK）级联反应控制，这些级联反应在转录和转录后水平调节不同的AP-1组分。最近，AP-1已被证明是一种氧化还原敏感的转录因子，在促氧化和抗氧化条件下均可被诱导。在本综述中，我们总结了汇聚于AP-1激活的信号通路以及这些通路中已被证明是抗氧化剂作用靶点的组分。抗氧化剂对AP-1的激活可能解释了许多在生理条件下介导重要功能的基因的表达。
