Porst H
Int J Impot Res. 1997 Dec;9(4):187-92. doi: 10.1038/sj.ijir.3900318.
A comparative study in 103 unselected patients with erectile dysfunction between MUSE up to 1000 micrograms and intracavernous Alprostadil (Prostavasin) up to 20 micrograms provided total response-rates of 43% (MUSE) vs 70% (Prostavasin). Complete rigid erections were reached in 10% (MUSE) vs 48% (Prostavasin). The average end-diastolic flow values in the deep penile arteries ranged between 9.2-9.4 cm/s after MUSE and 4.5-4.8 cm/s after i.c. Alprostadil confirming the investigator's assessment, that in the vast majority of patients MUSE were not able to induce a complete cavernous smooth muscle relaxation. In terms of side effects the reported penile pain/ burning-rate after MUSE was 31.4% compared to 10.6% after i.c. Alprostadil. In addition after MUSE clinically relevant systemic side-effects like dizziness, sweating and hypotension occurred in 5.8% with syncope in 1%. No circulatory side-effects were encountered after i.c. Alprostadil. Urethral bleeding after MUSE-application was observed in 4.8%. Due to the superior efficacy and lower side-effects self-injection therapy with Alprostadil remains the 'Gold Standard' in the management of male impotence. MUSE should be reserved for a subset of patients suffering from erectile dysfunction.
一项针对103例未经挑选的勃起功能障碍患者的对比研究，比较了使用剂量高达1000微克的前列地尔尿道栓（MUSE）与海绵体内注射剂量高达20微克的前列地尔（Prostavasin）的效果，结果显示总有效率分别为43%（MUSE）和70%（Prostavasin）。达到完全坚硬勃起的比例分别为10%（MUSE）和48%（Prostavasin）。使用MUSE后阴茎深动脉舒张末期平均血流速度在9.2 - 9.4厘米/秒之间，而海绵体内注射前列地尔后该数值在4.5 - 4.8厘米/秒之间，这证实了研究者的评估，即绝大多数患者使用MUSE后无法诱导海绵体平滑肌完全松弛。在副作用方面，使用MUSE后报告的阴茎疼痛/灼烧率为31.4%，而海绵体内注射前列地尔后为10.6%。此外，使用MUSE后出现临床相关的全身性副作用如头晕、出汗和低血压的比例为5.8%，晕厥比例为1%。海绵体内注射前列地尔后未出现循环系统副作用。使用MUSE后观察到尿道出血的比例为4.8%。由于疗效更佳且副作用更低，海绵体内注射前列地尔自我注射疗法仍是男性阳痿治疗的“金标准”。MUSE应仅用于一部分患有勃起功能障碍的患者。
