Azaz-Livshits T L, Danenberg H D
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Pharmacopsychiatry. 1997 Nov;30(6):274-5. doi: 10.1055/s-2007-979508.
The use of the selective serotonin reuptake inhibitor fluoxetine is associated with only minor cardiovascular effects. However, due to a possible inhibitory effect on the metabolism of calcium channel blockers it may potentiate the activity of nifedipine, causing profound adverse cardiovascular effects. This report describes the appearance of profound weakness, orthostatic hypotension and tachycardia following the initiation of fluoxetine treatment in a nifedipine-treated 80-year-old patient.
选择性5-羟色胺再摄取抑制剂氟西汀的使用仅与轻微的心血管效应相关。然而，由于其可能对钙通道阻滞剂的代谢产生抑制作用，它可能增强硝苯地平的活性，从而引起严重的不良心血管效应。本报告描述了一名接受硝苯地平治疗的80岁患者在开始使用氟西汀治疗后出现严重乏力、体位性低血压和心动过速的情况。
