Thomas S M, Brugge J S
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.
Annu Rev Cell Dev Biol. 1997;13:513-609. doi: 10.1146/annurev.cellbio.13.1.513.
Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and participate in signaling pathways that control a diverse spectrum of receptor-induced biological activities. While several of these kinases have evolved to play distinct roles in specific receptor pathways, there is considerable redundancy in the functions of these kinases, both with respect to the receptor pathways that activate these kinases and the downstream effectors that mediate their biological activities. This chapter reviews the evidence implicating Src family kinases in specific receptor pathways and describes the mechanisms leading to their activation, the targets that interact with these kinases, and the biological events that they regulate.
Src家族蛋白酪氨酸激酶在许多不同类型的细胞受体被激活后也随之被激活，并参与信号通路，这些信号通路控制着各种各样受体诱导的生物活性。虽然这些激酶中的几种已进化到在特定受体通路中发挥不同作用，但这些激酶的功能存在相当大的冗余，无论是在激活这些激酶的受体通路方面，还是在介导其生物活性的下游效应器方面。本章回顾了Src家族激酶参与特定受体通路的证据，并描述了导致其激活的机制、与这些激酶相互作用的靶点以及它们所调节的生物学事件。
