Kacmarek R M
Department of Anesthesia, Harvard Medical School, Boston, Massachusetts, USA.
Respir Care Clin N Am. 1997 Dec;3(4):551-68.
It is clear that NO in the lung has a major role beyond the modulation of pulmonary vasculature. NO appears to be involved in both the acute and chronic inflammatory response of many pulmonary cell types, as well as being partly responsible for modulating bronchial tone via the nonadrengeric noncholinergic system. Although the application of inhaled NO for the treatment of acute alternations of bronchial tone appears promising from animal data, the use of inhaled NO in patients has failed to reverse increased bronchial tone to a clinically significant level. Albuterol has better bronchodilating properties than inhaled NO. Monitoring exhaled NO, however, can provide an indicator of both acute and chronic lung inflammation. Much more work needs to be done before the monitoring of exhaled NO in pulmonary inflammatory disease can be recommended, but the preliminary data do indicate, as proposed by others, that exhaled NO may be a useful noninvasive measure of pulmonary inflammation and disease severity.
显然，肺内的一氧化氮（NO）在调节肺血管系统之外还有着重要作用。NO似乎参与了多种肺细胞类型的急性和慢性炎症反应，并且部分负责通过非肾上腺素能非胆碱能系统调节支气管张力。尽管从动物实验数据来看，吸入NO用于治疗支气管张力的急性改变似乎很有前景，但在患者中使用吸入NO未能将增加的支气管张力逆转至具有临床意义的水平。沙丁胺醇比吸入NO具有更好的支气管扩张特性。然而，监测呼出的NO可以为急性和慢性肺部炎症提供一个指标。在推荐将呼出NO监测用于肺部炎症性疾病之前，还需要做更多的工作，但初步数据确实如其他人所提出的那样表明，呼出NO可能是一种有用的、用于评估肺部炎症和疾病严重程度的非侵入性方法。
