Heimann G, Twarock-Bergt B, Gladtke E
Klin Padiatr. 1976 Mar;188(2):124-30.
The elimination of phenol-red was examined in 124 children without renal diseases. The normal values of the kinetic parameters were determined after intravenous injection of 3-4 mg dye per kg bodyweight. The elimination-half-life, which is independent from bodyweight and length was used as measure for the renal tubular secretion. In newborns (85,8 min) and young infants up to the age of 6 months (25,4 min) elimination-half-lives were longer than in older ones. After the second year of life (19,7 min) normal values of adults could be determined. The total clearance of phenol-red is smaller in newborns (185 ml/kg/h) than in children older than one year (643 ml/kg/h). Prematures had a longer elimination-half-life and a smaller total clearance than mature newborns.
对124名无肾脏疾病的儿童进行了酚红清除情况的检查。在按每千克体重静脉注射3 - 4毫克染料后，测定了动力学参数的正常值。消除半衰期与体重和身长无关，被用作肾小管分泌的指标。新生儿（85.8分钟）和6个月以下的幼儿（25.4分钟）的消除半衰期比年龄较大者更长。在生命的第二年之后（19.7分钟），可确定为成人的正常值。新生儿的酚红总清除率（185毫升/千克/小时）低于1岁以上儿童（643毫升/千克/小时）。早产儿的消除半衰期比足月新生儿更长，总清除率更小。
