八肽胆囊收缩素促进大鼠下丘脑5-羟色胺的释放。

CCK-8S facilitates 5-HT release in the rat hypothalamus.

作者信息

Voigt J P, Sohr R, Fink H

机构信息

Institute of Pharmacology and Toxicology, Humboldt University, Berlin, Germany.

出版信息

Pharmacol Biochem Behav. 1998 Jan;59(1):179-82. doi: 10.1016/s0091-3057(97)00315-8.

DOI:10.1016/s0091-3057(97)00315-8

PMID:9443553

Abstract

The effects of the neurotransmitter serotonin (5-HT) and the neuropeptide cholecystokinin (CCK) on food intake are well established. Based on pharmacological studies, an interactive model for 5-HT and CCK was proposed. The present microdialysis study was aimed to provide neurochemical evidence for a facilitatory effect of CCK-8S on 5-HT release in the lateral hypothalamus under in vivo conditions. The results indicate an increase of extracellular hypothalamic 5-HT both during food intake in previously food-deprived rats and also after systemic administration of 8 microg/kg and 40 microg/kg CCK-8s in food-deprived rats. The results show that peripherally administered CCK-8s induces central serotonergic effects, possibly related to feeding.

摘要

神经递质5-羟色胺（5-HT）和神经肽胆囊收缩素（CCK）对食物摄入的影响已得到充分证实。基于药理学研究，提出了5-HT和CCK的相互作用模型。本微透析研究旨在为体内条件下CCK-8S对下丘脑外侧5-HT释放的促进作用提供神经化学证据。结果表明，在先前饥饿的大鼠进食期间以及在饥饿大鼠中全身注射8微克/千克和40微克/千克CCK-8S后，下丘脑细胞外5-HT均增加。结果表明，外周给予CCK-8S可诱导中枢5-羟色胺能效应，这可能与进食有关。