Stopfkuchen H, Jüngst B K, Wilutzky H
Klin Padiatr. 1976 Mar;188(2):190-3.
We report about a 10 5/12 years old boy, who developed the rare disease of Purpura fulminans following Varicella, after having received the trivalent Poliomyelitis vaccine of Sabin and a diphtheria-tetanus booster during the incubation period of Varicella. The acute stage of the disease was overcome by symptomatic therapy; extensive skin necrosis especially in the lower extremities had to be treated surgically. The etiology of Purpura fulminans has not yet been established. Since diffuse intravascular clotting (DIC) plays an essential part in the pathogenesis of this disease. Heparintherapy is now used as the treatment of choice. At the present state of knowledge we believe that the protective inoculations given in the incubation period of Varicella possibly provoced Purpura fulminans as a rare complication of Varicella.
我们报告了一名10又5/12岁的男孩，他在水痘潜伏期接种了三价脊髓灰质炎减毒活疫苗（Sabin株）和白喉-破伤风加强疫苗后，患上了水痘后罕见的暴发性紫癜。通过对症治疗度过了疾病的急性期；尤其是下肢广泛的皮肤坏死必须进行手术治疗。暴发性紫癜的病因尚未明确。由于弥漫性血管内凝血（DIC）在该疾病的发病机制中起重要作用，肝素疗法现已成为首选治疗方法。就目前的知识水平而言，我们认为在水痘潜伏期进行的预防接种可能引发了暴发性紫癜，这是水痘的一种罕见并发症。
