Fujimura T, Yokota M, Kato S, Hirayama H, Tsunekawa A, Inagaki H, Takatsu F, Nakashima N, Yamada Y
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Am J Hypertens. 1997 Dec;10(12 Pt 1):1384-90. doi: 10.1016/s0895-7061(97)00323-3.
The association of an insertion/deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene or the serum activity of ACE with coronary artery disease (CAD) was investigated in Japanese men and women. The ACE genotype of 947 CAD subjects who underwent coronary angiography and of 893 control subjects was determined by polymerase chain reaction analysis. No association of the DD genotype or the D allele with CAD was observed in men or women. In a low risk group (defined by a body mass index below the median value and the absence of a history of hypertension, diabetes mellitus, and hypercholesterolemia), there was also no association between the ACE gene polymorphism and CAD. No significant difference in serum ACE activity was detected between CAD subjects and controls of all genotypes or of the same genotype, whereas a significant association was apparent between serum ACE activity and ACE genotype for both CAD subjects and controls among both men and women. These results indicate that the ACE I/D polymorphism and genotype associated variation in serum ACE activity are not risk factors for CAD in Japanese men or women.
在日本男性和女性中，研究了血管紧张素转换酶（ACE）基因中的插入/缺失（I/D）多态性或ACE的血清活性与冠状动脉疾病（CAD）之间的关联。通过聚合酶链反应分析确定了947例接受冠状动脉造影的CAD患者和893例对照者的ACE基因型。在男性或女性中，未观察到DD基因型或D等位基因与CAD之间存在关联。在低风险组（定义为体重指数低于中位数且无高血压、糖尿病和高胆固醇血症病史）中，ACE基因多态性与CAD之间也无关联。在所有基因型或相同基因型的CAD患者与对照者之间，未检测到血清ACE活性有显著差异，而在男性和女性的CAD患者与对照者中，血清ACE活性与ACE基因型之间均存在显著关联。这些结果表明，ACE I/D多态性以及血清ACE活性中与基因型相关的变异并非日本男性或女性患CAD的危险因素。
