Furlow T W, Bass N H
Neurology. 1976 Apr;26(4):297-304. doi: 10.1212/wnl.26.4.297.
Unilateral cerebrovascular occlusion was produced in heparinized rats within seconds after injection of microgram quantities of sodium arachidonate into the internal carotid artery. Electroencephalographic activity over the affected cerebral hemisphere became attenuated, and cerebral blood flow decreased by half. A neurologic syndrome, including ipsilateral blindness and contralateral sensorimotor deficits, resulted from occlusion of the microvasculature by platelet thrombi. Although aspirin strongly inhibited arachidonate-induced platelet aggregation in vitro, the drug offered little protection against arachidonate-induced stroke.
在向肝素化大鼠的颈内动脉注射微克量的花生四烯酸钠后数秒内造成单侧脑血管闭塞。受影响的大脑半球的脑电图活动减弱，脑血流量减少一半。血小板血栓阻塞微血管导致了一种神经综合征，包括同侧失明和对侧感觉运动缺陷。尽管阿司匹林在体外能强烈抑制花生四烯酸诱导的血小板聚集，但该药物对花生四烯酸诱导的中风几乎没有保护作用。
