轴突导向：小GTP酶帮助轴突抵达其靶标。

Axon guidance: GTPases help axons reach their targets.

作者信息

Gallo G, Letourneau P C

机构信息

Department of Cell Biology and Neuroanatomy, 4-144 Jackson Hall, The University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

Curr Biol. 1998 Jan 29;8(3):R80-2. doi: 10.1016/s0960-9822(98)70051-x.

DOI:10.1016/s0960-9822(98)70051-x

PMID:9443904

Abstract

During development and regeneration of the nervous system, axons must correctly navigate to their specific targets through a complex molecular environment. Recent work has shed light on how GTPases of the Ras family are involved in transducing extracellular signals into responses that lead to directed neurite outgrowth.

摘要

在神经系统的发育和再生过程中，轴突必须在复杂的分子环境中正确地导航至其特定靶点。最近的研究揭示了Ras家族的GTPases如何参与将细胞外信号转化为导致定向神经突生长的反应。