Snider S R, Fahn S, Isgreen W P, Cote L J
Neurology. 1976 May;26(5):423-9. doi: 10.1212/wnl.26.5.423.
Forty-three of 101 outpatients with parkinsonism reported that they regularly experienced primary sensory symptoms, i.e., spontaneous abnormal sensations not caused by somatic disease. This is in contrast to similar symptoms reported by only 8 percent of a control population. The most striking and severe symptom was burning of the trunk and proximal extremities, occurring in 11 patients. Twenty-nine patients reported spontaneous pain; a variety of other paresthesialike sensations, e.g., tingling, numbness, and formication, occurred in 32 patients. These subjective sensory phenomena were not associated with sensory loss or autonomic or motor signs. In 20 percent of affected individuals (9 percent of the total), sensory symptoms preceded the onset of the movement disorder, causing difficulty in diagnosis. It is concluded that at least some sensory symptoms originate within the nervous system as a manifestation of the disease process and are not secondary effects of the motor disorder.
101 名帕金森病门诊患者中有 43 人报告称他们经常经历原发性感觉症状，即并非由躯体疾病引起的自发异常感觉。这与对照组中仅有 8% 的人报告的类似症状形成对比。最显著和严重的症状是 11 名患者出现的躯干和近端肢体灼痛。29 名患者报告有自发疼痛；32 名患者出现了各种其他类似感觉异常的感觉，如刺痛、麻木和蚁走感。这些主观感觉现象与感觉丧失、自主神经或运动体征无关。在 20% 的受影响个体（占总数的 9%）中，感觉症状先于运动障碍出现，导致诊断困难。得出的结论是，至少一些感觉症状起源于神经系统，是疾病过程的一种表现，而非运动障碍的继发效应。
