Flohr H, Breull W, Dahners H W, Redel D, Conradi H, Stoepel K
Pflugers Arch. 1976 Mar 30;362(2):157-64. doi: 10.1007/BF00583642.
The regional distribution of the peripheral vascular resistance was studied in normotensive and hypertensive Wistar rats. Two models of experimental hypertension were investigated: (I) in 32 animals the right renal artery was constricted by a silver clip (two-kidney Goldblatt hypertension); (II) in 46 animals the left kidney was removed and the right renal artery was clipped as in the first group (one-kidney Goldblatt hypertension). The normotensive control group comprised 61 untreated animals of the same strain and age. The distribution of cardiac output to 14 tissues was determined by means of the particle distribution technique. The resistance was increased in all regions investigated, a decreased or unchanged resistance was not observed. For most of the investigated tissues the regional resistance was increased exactly in proportion to the total peripheral resistance (TPR). Exceptions to this were found in 2 regions where the change of local resistance deviated from that of TPR: the splanchnic area and the skeletal muscle. In both cases the 2 models differed from each other. In the two-kidney model the increase of resistance in the splanchnic circulation was more intense than in other organs. In contrast, in the one-kidney model the local change of resistance was less than that of TPR. The change of skeletal muscle resistance was not significantly different from the change of TPR in the two-kidney model, while in the one-kidney model the increase of local resistance was significantly higher than that of TPR. It is concluded that the etiology of the abnormal resistance is different in the 2 models investigated and that known extrinsinc pressor factors may play a role in the two-kidney, but not in the one-kidney Goldblatt hypertension.
研究了正常血压和高血压Wistar大鼠外周血管阻力的区域分布。研究了两种实验性高血压模型：（I）在32只动物中，用银夹夹闭右肾动脉（两肾型Goldblatt高血压）；（II）在46只动物中，切除左肾，并如第一组那样夹闭右肾动脉（单肾型Goldblatt高血压）。正常血压对照组包括61只相同品系和年龄的未处理动物。通过颗粒分布技术测定心输出量在14个组织中的分布。在所研究的所有区域中阻力均增加，未观察到阻力降低或不变的情况。对于大多数研究组织，区域阻力的增加与总外周阻力（TPR）的增加完全成比例。在2个区域发现了例外情况，即局部阻力的变化与TPR的变化不同：内脏区域和骨骼肌。在这两种情况下，两种模型彼此不同。在两肾模型中，内脏循环阻力的增加比其他器官更强烈。相比之下，在单肾模型中，局部阻力的变化小于TPR的变化。在两肾模型中，骨骼肌阻力的变化与TPR的变化无显著差异，而在单肾模型中，局部阻力的增加显著高于TPR的增加。得出的结论是，在所研究的两种模型中，异常阻力的病因不同，已知的外在升压因素可能在两肾型Goldblatt高血压中起作用，但在单肾型Goldblatt高血压中不起作用。
