Inagaki-Ohara K, Sakai T, Koya G, Awaya A, Yoshikai Y
Laboratory of Host Defense, Nagoya University School of Medicine, Aichi, Japan.
Microbiol Immunol. 1997;41(11):883-9. doi: 10.1111/j.1348-0421.1997.tb01945.x.
We have previously reported that a nonapeptide thymic hormone, facteur thymique serique (FTS), is involved in the differentiation and activation of intestinal intraepithelial lymphocytes (i-IEL) in mice. In this study, we examined the effect of FTS treatment on enteropathy in a murine model for acute graft-vs.-host disease (GVHD) induced by injection of parental C57BL/6 splenocytes into unirradiated (C57BL/6 x DBA/2) F1 hybrids. FTS treatment significantly protected mice from developing acute GVHD as assessed by mortality rate, splenomegaly and enteropathy. The infiltration of donor-derived TCR alpha beta i-IEL bearing CD8 alpha beta was significantly inhibited in the small intestine of FTS-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute GVHD. These results suggest that FTS treatment contributes to protection against enteropathy of acute GVHD. Thus, FTS may provide a useful approach to control acute GVHD after blood transfusion or bone marrow transplantation.
我们之前报道过，一种九肽胸腺激素，血清胸腺因子（FTS），参与小鼠肠道上皮内淋巴细胞（i-IEL）的分化和激活。在本研究中，我们检测了FTS处理对小鼠急性移植物抗宿主病（GVHD）模型肠道病变的影响，该模型通过将亲代C57BL/6脾细胞注射到未受照射的（C57BL/6×DBA/2）F1杂种小鼠中诱导产生。通过死亡率、脾肿大和肠道病变评估，FTS处理显著保护小鼠免受急性GVHD的发展。在FTS处理的小鼠小肠中，携带CD8αβ的供体来源TCRαβ i-IEL的浸润显著受到抑制，并且在急性GVHD期间，这些小鼠肠道黏膜隐窝细胞的凋亡频率降低。这些结果表明，FTS处理有助于预防急性GVHD的肠道病变。因此，FTS可能为控制输血或骨髓移植后的急性GVHD提供一种有用的方法。
