O'Neill R D, Lowry J P, Mas M
Department of Chemistry, University College Dublin, Belfield, Ireland.
Crit Rev Neurobiol. 1998;12(1-2):69-127. doi: 10.1615/critrevneurobiol.v12.i1-2.40.
Clinical intervention in neurological disorders is almost invariably achieved using chemical agents that act on neuromediator-related sites, suggesting that intercellular chemical signaling plays a major role in determining the properties of neural networks. A variety of microvoltammetric sensors and techniques have been developed over the last 25 years to study neuromediators in intact brain in vivo, and in isolated tissues, for animal models of behavior and disease. This review, with over 600 citations, considers the advantages and limitations of the different approaches, including progress in biosensor design, illustrated by studies on the neurochemical bases of a wide variety of behaviors.
神经疾病的临床干预几乎总是通过作用于神经递质相关位点的化学药剂来实现，这表明细胞间化学信号传导在决定神经网络特性方面发挥着主要作用。在过去25年里，已经开发出了各种各样的微伏安传感器和技术，用于在体内完整大脑以及分离组织中研究神经递质，以建立行为和疾病的动物模型。这篇综述引用了600多篇文献，探讨了不同方法的优缺点，包括生物传感器设计方面的进展，并通过对多种行为的神经化学基础的研究加以说明。
