Fukuzako H, Yamada K, Kodama S, Yonezawa T, Fukuzako T, Takenouchi K, Kajiya Y, Nakajo M, Takigawa M
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Eur Arch Psychiatry Clin Neurosci. 1997;247(5):248-51. doi: 10.1007/BF02900302.
To determine whether there are disturbances of hippocampal volume asymmetry in schizophrenic patients, we obtained contiguous, 1-mm-thick magnetic resonance images in 28 males with chronic schizophrenia and in 28 age-matched healthy males. The schizophrenic patients showed a bilateral reduction in volume of the hippocampal formation (HF; left 7.0%; right 8.7%). This reduction was significantly associated with the severity of disorganization syndrome (P < 0.0005). A significant asymmetry in the HF volume was found in the control subjects (P = 0.006), but not in the patients (P = 0.40). There was a significant positive correlation between the asymmetry index and the patient's age at the onset of schizophrenia (r = 0.46, P = 0.01). Results indicate that a disturbance in the normal asymmetry of the HF may be a characteristic in schizophrenia, particularly in patients with an early onset of the illness.
为了确定精神分裂症患者是否存在海马体体积不对称性紊乱，我们对28名患有慢性精神分裂症的男性和28名年龄匹配的健康男性进行了连续的、厚度为1毫米的磁共振成像检查。精神分裂症患者双侧海马结构（HF）体积均减小（左侧7.0%；右侧8.7%）。这种减小与紊乱综合征的严重程度显著相关（P < 0.0005）。在对照组中发现HF体积存在显著不对称性（P = 0.006），但在患者中未发现（P = 0.40）。不对称指数与精神分裂症发病时患者的年龄之间存在显著正相关（r = 0.46，P = 0.01）。结果表明，HF正常不对称性的紊乱可能是精神分裂症的一个特征，尤其是在疾病早期发病的患者中。
