外侧缰核与海马体：一种由中缝核细胞介导的复杂相互作用。
Lateral habenula and hippocampus: a complex interaction raphe cells-mediated.
作者信息
Ferraro G, Montalbano M E, Sardo P, La Grutta V
机构信息
Institute of Human Physiology, University of Palermo, Italy.
出版信息
J Neural Transm (Vienna). 1997;104(6-7):615-31. doi: 10.1007/BF01291880.
The study has shown an excitatory influence exerted by lateral habenula (LH) on hippocampal pyramidal cells. The modulatory influence is paradoxically serotonine-mediated; in fact all LH stimulation effects were abolished by intrahippocampal iontophoretic methysergide application. The data suggest the involvement of dorsal raphe nucleus. In fact, the dorsal raphe nucleus stimulation caused on hippocampus an expected inhibitory effect antagonized by intrahippocampal iontophoretic methysergide application. In the context of this neural structure we have highlighted a disinhibitory relation between two types of cells: slow serotonergic efferent neurones and fast GABAergic interneurones. The disinhibitory hypothesis is also supported by the following experimental tests performed on both slow and fast raphe cells: a) LH stimulation at low and high frequencies; b) iontophoretic administration of NMDA and GABA; c) LH stimulation during intraraphe iontophoretic injection of 2-APV (NMDA antagonist) and bicuculline (GABA antagonist).
该研究表明，外侧缰核（LH）对海马锥体细胞有兴奋作用。矛盾的是，这种调节作用是由血清素介导的；事实上，海马内离子电渗法应用美西麦角可消除所有LH刺激效应。数据表明中缝背核参与其中。事实上，刺激中缝背核会对海马产生预期的抑制作用，而海马内离子电渗法应用美西麦角可拮抗这种作用。在这种神经结构的背景下，我们强调了两种类型细胞之间的去抑制关系：慢速血清素能传出神经元和快速GABA能中间神经元。对慢速和快速中缝细胞进行的以下实验测试也支持去抑制假说：a）低频和高频刺激LH；b）离子电渗法给予NMDA和GABA；c）在中缝内离子电渗注射2-APV（NMDA拮抗剂）和荷包牡丹碱（GABA拮抗剂）期间刺激LH。
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