绵羊孕期血浆中13,14-二氢-15-酮-前列腺素F的浓度

Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F during pregnancy in sheep.

作者信息

Mitchell M D, Flint A P, Turnbull A C

出版信息

Prostaglandins. 1976 Feb;11(2):319-29. doi: 10.1016/0090-6980(76)90154-4.

Abstract

A specific and sensitive radioimmunoassay is decribed for 13,14-dihydro-15-keto-prostaglandin F in ovine plasma. Using this assay it has been shown that, in sheep, jugular venous 13,14-dihydro-15-keto-prostaglandin F concentrations increase at parturition and correlate well with concentrations of prostaglandin F in the utero-ovarian vein. It is suggested that uterine prostaglandin F production under these conditions may be assessed by measuring peripheral venous 13,14-dihydro-15-keto-prostaglandin F, thereby avoiding the need for chronic utero-ovarian venous catheters.

摘要

本文描述了一种用于测定绵羊血浆中13,14-二氢-15-酮-前列腺素F的特异性和灵敏性放射免疫分析法。利用该分析法已表明，在绵羊中，分娩时颈静脉13,14-二氢-15-酮-前列腺素F浓度升高，且与子宫卵巢静脉中前列腺素F的浓度密切相关。有人提出，在这些情况下，可通过测量外周静脉13,14-二氢-15-酮-前列腺素F来评估子宫前列腺素F的产生，从而无需长期留置子宫卵巢静脉导管。