术中在兔眼一体式青光眼滤过植入物下注射透明质酸的效果。
The effect of intraoperative injection of hyaluronan under a one-piece glaucoma filtration implant in the rabbit eye.
作者信息
Kivalo M, Hollmén T, Sukura A, Mononen T
机构信息
Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland.
出版信息
Acta Vet Scand. 1997;38(3):235-42. doi: 10.1186/BF03548486.
The effect of a single intraoperative injection of hyaluronan on intraocular pressure (IOP) and postsurgical tissue healing was evaluated on 18 rabbits with an aqueous drainage implant. During the follow-up period IOP was recorded and analysed. Furthermore, inflammatory reaction and appearance of the fibrous tissue around the implants were studied in histological sections. In both the hyaluronan and control groups the operation lowered the average IOP statistically significantly for the whole follow-up period when compared with preoperative values. From days 7 to 60 the mean IOP values of the hyaluronan injected eyes stayed at a lower level than in the control eyes, but with no statistical difference between the 2 groups. The connective tissue layer around the implants appeared less dense during the first 17 postoperative days in the sodium-hyaluronate group; in addition, the inflammatory cell reaction showed a tendency to remain acute longer.
在18只植入房水引流装置的兔子身上评估了术中单次注射透明质酸对眼压（IOP）和术后组织愈合的影响。在随访期间记录并分析眼压。此外，在组织学切片中研究了植入物周围的炎症反应和纤维组织外观。与术前值相比，在整个随访期间，透明质酸组和对照组的手术均使平均眼压在统计学上显著降低。从第7天到第60天，注射透明质酸的眼睛的平均眼压值低于对照眼，但两组之间无统计学差异。在术后的前17天，透明质酸钠组植入物周围的结缔组织层看起来密度较低；此外，炎症细胞反应显示出急性持续时间更长的趋势。
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