Kemper M J, Altrogge H, Amon O, Müller-Wiefel D E
Universitäts-Kinderklinik Eppendorf.
Klin Padiatr. 1997 Nov-Dec;209(6):373-6. doi: 10.1055/s-2008-1043978.
Haematuria and proteinuria are important symptoms of primary and secondary nephropathies. We report three african children presenting to our center in whom infection with S. haematobium resulted in haematuria and proteinuria. The third patient concomitantly suffered from steroid-sensitive relapsing nephrotic syndrome with the histological features of focal and segmental glomerulo-sclerosis. The diagnosis was in all cases established by light microscopy and urinary symptoms improved after treatment with praziquantel. In the third patients long term remission of the nephrotic syndrome could be maintained after 4 doses of praziquantel for recurrent bladder symptoms. We conclude that bilharziosis must be considered in the differential diagnosis of children with haeamturia and proteinuria even in Europe. The diagnosis can be established easily by light microscopy and an effective and low-risk treatment (with Praziquantel) can be offered.
血尿和蛋白尿是原发性和继发性肾病的重要症状。我们报告了三名到我们中心就诊的非洲儿童,他们感染埃及血吸虫后出现了血尿和蛋白尿。第三名患者同时患有类固醇敏感型复发性肾病综合征,具有局灶节段性肾小球硬化的组织学特征。所有病例均通过光学显微镜确诊,吡喹酮治疗后尿路症状有所改善。在第三名患者中,因膀胱症状复发,服用4剂吡喹酮后肾病综合征得以长期缓解。我们得出结论,即使在欧洲,对于有血尿和蛋白尿的儿童进行鉴别诊断时也必须考虑血吸虫病。通过光学显微镜可轻松确诊,并且可以提供有效且低风险的治疗方法(使用吡喹酮)。