Triolo O, Fattori A, Commisso S, Maimone A, Granese D
Istituto di Ginecologia e Ostetricia, Università degli Studi, Messina.
Minerva Ginecol. 1997 Sep;49(9):383-91.
This study reports the results obtained in the medical introduction of abortion during the second trimester of pregnancy in 52 patients following intrauterine fetal death or the diagnosis of fetal malformations.
The protocol consisted of the alternate use of intravaginal suppositories of gemeprost and intramuscular injections of sulprostone. The results were analysed using statistical methods and evaluated in relation to the different parameters present (intrauterine fetal death or therapeutic abortion, maternal age, gestation period and parity).
It was seen that the time required to induce abortive labour was significantly shorter in patients with IFD compared to patients with live fetus. The comparison between patients with a gestation period < or > 18 weeks revealed shorter induction times in the former group without reaching statistical significance.
Maternal age (under and over 30) and parity (P = 0 and P > or = 1) did not influence the results obtained.
本研究报告了52例因宫内胎儿死亡或诊断为胎儿畸形而在妊娠中期进行药物引产的患者的结果。
方案包括交替使用米索前列醇阴道栓剂和注射磺前列酮。使用统计方法分析结果，并根据存在的不同参数（宫内胎儿死亡或治疗性流产、产妇年龄、妊娠期和产次）进行评估。
发现与活胎患者相比，宫内胎儿死亡患者引产所需时间明显更短。妊娠期<或>18周的患者之间的比较显示，前一组引产时间较短，但未达到统计学意义。
产妇年龄（30岁以下和30岁以上）和产次（P = 0和P>或 = 1）不影响所得结果。
