Koch J, Greminger P, Simeon-Dubach D
Medizinische Poliklinik, Universitätsspital Zürich.
Praxis (Bern 1994). 1997 Nov 5;86(45):1779-84.
The necessity for a persistent antihypertensive treatment in elderly persons has not been proven until the beginning nineties. An adequate reduction of blood pressure is required also in high age for prevention of cardiovascular accidents. A study is presented which investigates efficacy and tolerance of the ACE-inhibitor fosinopril in an unselected cohort of hypertensive outpatients older than 60 years over 12 weeks. Diastolic hypertension (DBP > or = 96-110 mm Hg) and isolated systolic hypertension (SBP > or = 160-219 mm Hg, DBP 80-94 mm Hg) were analyzed separately. Blood pressure values in both groups were normalized in more than 80% of the patients. In the case of insufficient response an additional dose of 12.5 mg hydrochlorochiazide was somewhat more effective than doubling the dose of the ACE-inhibitor. Efficacy and side effects of the antihypertensive treatment with fosinopril in this study were not dependent on the degree of impaired renal function.
直到九十年代初，老年患者持续进行抗高血压治疗的必要性才得到证实。高龄患者为预防心血管意外也需要充分降低血压。本文介绍了一项研究，该研究在12周内调查了未经过挑选的60岁以上高血压门诊患者使用ACE抑制剂福辛普利的疗效和耐受性。分别分析了舒张期高血压（舒张压≥96 - 110 mmHg）和单纯收缩期高血压（收缩压≥160 - 219 mmHg，舒张压80 - 94 mmHg）。两组中超过80%的患者血压值恢复正常。在反应不足的情况下，额外服用12.5 mg氢氯噻嗪比将ACE抑制剂剂量加倍更有效。本研究中福辛普利抗高血压治疗的疗效和副作用不依赖于肾功能受损程度。
