Fischer A, Lüdemann M, Schulte-Mönting J, Finke J, Imdahl A, Farthmann E H
Chirurgische Universitätsklinik, Abteilung Allgemeine Chirurgie und Poliklinik, Universität Freiburg.
Zentralbl Chir. 1997;122(10):901-8.
The postoperative outcome of 108 patients with soft tissue sarcoma (STS) of the extremities, the retroperitoneum, or the trunk was investigated retrospectively to identify independent factors for the over all survival and local tumor control. Chi-square single factor analysis and a Cox model were used to identify independent postoperative risk factors. Single factor analysis revealed a significant correlation with negative effect on overall survival for the variables metastasis (p < 0.0001), chemotherapy (p < 0.0009), surgical procedures (0.001), tumor size > 10 cm (p < 0.003), localization (retroperitoneum, trunk) (p < 0.03), and grading (G3/G4) (p < 0.03). Local tumor control was significantly correlated with the variable tumor size > 10 cm (p < 0.01). The Cox model showed a significant negative impact on overall survival for the factors metastasis (p < 0.002), tumor size > 10 cm (p < 0.004), grading (G3/G4) (p < 0.005), and sex (male) (p < 0.008). For local tumor control the variables were age (p < 0.006), and surgical procedures (p < 0.01).
对108例四肢、腹膜后或躯干软组织肉瘤（STS）患者的术后结果进行回顾性研究，以确定影响总生存和局部肿瘤控制的独立因素。采用卡方单因素分析和Cox模型来确定术后独立危险因素。单因素分析显示，转移（p < 0.0001）、化疗（p < 0.0009）、手术方式（0.001）、肿瘤大小>10 cm（p < 0.003）、部位（腹膜后、躯干）（p < 0.03）和分级（G3/G4）（p < 0.03）这些变量与总生存的负面影响显著相关。局部肿瘤控制与肿瘤大小>10 cm这一变量显著相关（p < 0.01）。Cox模型显示，转移（p < 0.002）、肿瘤大小>10 cm（p < 0.004）、分级（G3/G4）（p < 0.005）和性别（男性）（p < 0.008）这些因素对总生存有显著负面影响。对于局部肿瘤控制，变量为年龄（p < 0.006）和手术方式（p < 0.01）。
