Locatelli V, Torsello A
Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy.
Pharmacol Res. 1997 Dec;36(6):415-23. doi: 10.1006/phrs.1997.0253.
This review systematically analyses recent knowledge of the biology of the growth hormone-releasing peptides. Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity. Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.
本综述系统分析了近期关于生长激素释放肽生物学的知识。在天然生长激素释放激素（GHRH）被分离和测序的许多年前，一种脑啡肽类似物的合成促使人们设计了许多具有改善的生长激素释放活性的结构相关生长激素释放肽（GHRP），该脑啡肽类似物没有任何阿片样活性，但能够从体外垂体中特异性释放生长激素（GH）。如今，GHRP是已知最有效的生长激素促分泌素，可有益地用于患有生长激素分泌不足紊乱的人类，以促进一种生长激素分泌模式，这种模式比外源性给予的生长激素更好地模拟生理状态。
