Nardone L, Ausili-Cèfaro G, Palazzoni G, Gentile P C, Salvi G, Marmiroli L
Cattedra di Radioterapia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Roma, Italy.
Rays. 1997 Jul-Sep;22(3):417-24.
Aim of this study was to evaluate the feasibility, therapeutic effectiveness and toxicity of a non conventional radiation therapy (180 cGy twice a day for a total dose of 36 Gy in 2 weeks in the treatment of breast cancer inoperable with conservative surgery as first choice. Ten patients were studied. Results were as follows: complete response: 20%, partial response: 70%; no change: 10%. Acute toxicity was negligible and late toxicity, after a mean 46-month follow-up, was practically absent; the cosmetic result was definitely good. The radiobiology and kinetic features of breast cancer indicate that the potential of accelerated treatment should be further explored, this fractionation being suitable for optimal combined modality treatment with preoperative chemotherapy.
本研究的目的是评估一种非常规放射治疗（每天两次，每次180厘戈瑞，两周内总剂量达36戈瑞）对无法进行保守手术的乳腺癌作为首选治疗方法的可行性、治疗效果和毒性。研究了10名患者。结果如下：完全缓解率为20%，部分缓解率为70%，无变化率为10%。急性毒性可忽略不计，平均随访46个月后几乎没有迟发性毒性；美容效果肯定良好。乳腺癌的放射生物学和动力学特征表明，加速治疗的潜力应进一步探索，这种分割方式适合与术前化疗进行最佳联合治疗。
