Cupp M J, Tracy T S
West Virginia University School of Pharmacy, Morgantown, USA.
Am Fam Physician. 1998 Jan 1;57(1):107-16.
Many drug interactions are a result of inhibition or induction of cytochrome P450 enzymes (CYP450). The CYP3A subfamily is involved in many clinically significant drug interactions, including those involving nonsedating antihistamines and cisapride, that may result in cardiac dysrhythmias. CYP3A4 and CYP1A2 enzymes are involved in drug interactions involving theophylline. CYP2D6 is responsible for the metabolism of many psychotherapeutic agents. The protease inhibitors, which are used to treat patients infected with the human immunodeficiency virus, are metabolized by the CYP450 enzymes and consequently interact with a multitude of other medications. By understanding the unique functions and characteristics of these enzymes, physicians may better anticipate and manage drug interactions and may predict or explain an individual's response to a particular therapeutic regimen.
许多药物相互作用是细胞色素P450酶（CYP450）受到抑制或诱导的结果。CYP3A亚家族参与了许多具有临床意义的药物相互作用，包括那些涉及非镇静性抗组胺药和西沙必利的相互作用，这可能会导致心律失常。CYP3A4和CYP1A2酶参与了涉及茶碱的药物相互作用。CYP2D6负责许多精神治疗药物的代谢。用于治疗感染人类免疫缺陷病毒患者的蛋白酶抑制剂由CYP450酶代谢，因此会与多种其他药物发生相互作用。通过了解这些酶的独特功能和特性，医生可以更好地预测和处理药物相互作用，并可以预测或解释个体对特定治疗方案的反应。
