尿皮质素对人垂体生长激素腺瘤细胞生长激素（GH）分泌的刺激作用。

Stimulation by urocortin of growth hormone (GH) secretion in GH-producing human pituitary adenoma cells.

作者信息

Murakami Y, Mori T, Koshimura K, Kurosaki M, Hori T, Yanaihara N, Kato Y

机构信息

Department of Medicine, Shimane Medical University, Izumo, Japan.

出版信息

Endocr J. 1997 Aug;44(4):627-9. doi: 10.1507/endocrj.44.627.

DOI:10.1507/endocrj.44.627

PMID:9447301

Abstract

Urocortin (Ucn) possesses high homology with CRH and is considered to be a ligand to type-2 CRH receptor. We investigated the effect of Ucn on hormone release from cultured GH-producing human pituitary adenoma cells in vitro. GH-producing human pituitary adenoma cells were superfused on a Sephadex G-25 column. Both Ucn (10 nM) and CRH (10 nM) elicited an increase in GH release from the pituitary adenoma cells in one patient with acromegaly. In contrast, GH release from the pituitary adenoma cells was stimulated by Ucn but not by CRH in the other patient with acromegaly. These preliminary findings suggest that type-2 CRH receptors are expressed in some population of GH-producing human pituitary adenoma cells and that Ucn might be involved in GH secretion from tumorous tissues in patients with acromegaly.

摘要

尿皮质素（Ucn）与促肾上腺皮质激素释放激素（CRH）具有高度同源性，被认为是2型CRH受体的配体。我们在体外研究了Ucn对培养的产生长激素的人垂体腺瘤细胞激素释放的影响。将产生长激素的人垂体腺瘤细胞在葡聚糖G-25柱上进行灌流。在一名肢端肥大症患者中，Ucn（10 nM）和CRH（10 nM）均引起垂体腺瘤细胞生长激素释放增加。相比之下，在另一名肢端肥大症患者中，垂体腺瘤细胞的生长激素释放受到Ucn刺激，但不受CRH刺激。这些初步发现表明，2型CRH受体在一些产生长激素的人垂体腺瘤细胞群体中表达，并且Ucn可能参与肢端肥大症患者肿瘤组织的生长激素分泌。