The GUSTO trial and the open artery theory.

The GUSTO trials have provided continuing insight into the complexities of a simple fundamental relationship: early and sustained coronary perfusion in patients with acute myocardial infarction leads to lower mortality and morbidity. To a large extent, the GUSTO trials have attempted to develop approaches to therapy that will ensure the highest early rate of reperfusion with the least risk. A table provides a summary of the completed trials and those that are planned in attempts to provide further knowledge in the continuing quest to improve the plight of patients with acute myocardial infarction.