Gaynon M W, Stevenson D K, Sunshine P, Fleisher B E, Landers M B
Department of Ophthalmology, Stanford University, Calif., USA.
J Perinatol. 1997 Nov-Dec;17(6):434-8.
The optimum level of oxygen saturation for infants with prethreshold retinopathy of prematurity (ROP) is unknown. We reviewed our conversion rate from prethreshold to threshold ROP between 1985 and 1993 during which time target levels of oxygen saturation rose in a stepwise fashion. A retrospective study of 153 infants with prethreshold ROP was performed at Stanford University between 1985 and 1993 that showed that target minimum oxygen saturation rose from 92% (1985-1987) to 95% (1988) to 96% (1989) to 99% (1990-1993). In addition, we looked at 26 infants between 1994 and 1996 who were excluded from the STOP-ROP study and who were not receiving supplemental oxygen in an effort to maintain equipoise for that study. Infant characteristics were tabulated, and rates of progression from prethreshold to threshold ROP were calculated. Rates of progression to threshold varied little between 1985 and 1989 (average 37%), but dropped to 7% for the period between 1990 and 1993. From 1994 through 1996 the rate of progression to threshold disease rose again, to 38%. Moderate supplemental oxygen (target saturation 99% with PO2 no higher than 100 mm Hg) was associated with regression of prethreshold ROP, without appearing to arrest retinal vascular maturation.
阈值前早产儿视网膜病变（ROP）婴儿的最佳氧饱和度水平尚不清楚。我们回顾了1985年至1993年间从阈值前ROP转变为阈值ROP的转化率，在此期间氧饱和度的目标水平逐步上升。1985年至1993年期间，斯坦福大学对153例阈值前ROP婴儿进行了一项回顾性研究，结果显示目标最低氧饱和度从92%（1985 - 1987年）升至95%（1988年）、96%（1989年），再到99%（1990 - 1993年）。此外，我们研究了1994年至1996年间被排除在STOP - ROP研究之外且未接受补充氧气的26例婴儿，目的是为该研究保持平衡。将婴儿的特征制成表格，并计算从阈值前ROP进展为阈值ROP的发生率。1985年至1989年间进展为阈值ROP的发生率变化不大（平均为37%），但在1990年至1993年期间降至7%。从1994年到1996年，进展为阈值疾病的发生率再次上升，达到38%。中等剂量的补充氧气（目标饱和度99%，PO2不高于100 mmHg）与阈值前ROP的消退相关，且似乎并未阻止视网膜血管成熟。
