Nielsen N J
Tubercle. 1979 Dec;60(4):239-43. doi: 10.1016/0041-3879(79)90005-9.
Of 51 patients in Eastern Botswana who denied previous anti-tuberculosis treatment, 6 (11.8 %) were excreting tubercle bacilli resistant to one of the first-line drugs in regular use: 4 patients (7.8 %) showed resistance to isoniazid, 2 (3.9 %) to thiacetazone and none to streptomycin. Of 44 patients known to have been on previous anti-tuberculosis treatment, 31 (70.5 %) were found to show resistance to one or more of the first line drugs: 31 (70.5 %) to isoniazid, 12 (27.2 %) to streptomycin and 11 (25.9 %) to thiacetazone. No appreciable resistance was found to second line drugs. These resistance patterns, which correspond quite well with other published results from Africa, are related to the overall problem in Botswana, namely the failure of a high proportion of patients, to complete a full course of first line treatment.
在博茨瓦纳东部否认曾接受过抗结核治疗的51名患者中，有6名（11.8%）排出对一种常用一线药物耐药的结核杆菌：4名患者（7.8%）对异烟肼耐药，2名（3.9%）对氨硫脲耐药，对链霉素均无耐药。在已知曾接受过抗结核治疗的44名患者中，31名（70.5%）被发现对一种或多种一线药物耐药：31名（70.5%）对异烟肼耐药，12名（27.2%）对链霉素耐药，11名（25.9%）对氨硫脲耐药。未发现对二线药物有明显耐药。这些耐药模式与非洲其他已发表的结果相当吻合，与博茨瓦纳的总体问题有关，即很大一部分患者未能完成一线治疗的全程。
